Electrical response of glioma cells to acetylcholine.

  title={Electrical response of glioma cells to acetylcholine.},
  author={Bernd Hamprecht and W M Kemper and Taku Amano},
  journal={Brain research},
  volume={101 1},
A bromodeoxyuridine resistant mutant of rat gliom line C6 grown in the presence of N6,02'-dibutyryl adenosine-3':5'-cyclic monophosphate, although inexcitable by electrical current, responds to iontophoretic application of acetylcholine by slow hyperpolarization. The sensitivity to acetylcholine is strongly reduced by excessive amounts of acetylcholine. The hyperpolarization response is inhibited by atropine or alpha-bungarotoxin, but not by D-tubocurarine. In the absence of acetylcholine some… CONTINUE READING

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