Electrical properties of isolated perfused rabbit renal tubules.

Abstract

BURG, M. B., L. ISAACSON, J. GRANTHAM, AND J. ORLOFF. Electrical properties of isolated perfused rabbit renal tub&s. Am. J. Physiol. 2 15(4) : 788-794. 1968.-Electrical potential difference (PD) was measured across isolated perfused rabbit proximal renal tubules and collecting tubules in vitro. In the collecting tubule the PD stabilized after 2-3 hr of perfusion at a mean value of 25 mv (lumen negative). Ouabain caused depolarization, interpreted as indicating that the PD may be related to active Na+ transport. Vasopressin caused a transient increase in PD followed bv a sustained decrease. Electrical resistante of the collecting tubule wall was evaluated from measurements of the length constant for the decay of PD from a current source within the tubule lumen. This calculated resistance is much greater than that previously found in rat proximal tubule in vivo. . In proximal convoluted tubules under conditions optimal for net fluid absorption mean PD was -0.7 mv. This is in agreement with the recent finding that there is no measurable PD in rat proximal convoluted tubules in vivo.

7 Figures and Tables

Statistics

0100200300'03'05'07'09'11'13'15'17
Citations per Year

175 Citations

Semantic Scholar estimates that this publication has 175 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Burg1968ElectricalPO, title={Electrical properties of isolated perfused rabbit renal tubules.}, author={Maurice B. Burg and L Issaacson and Jared J. Grantham and Jack Orloff}, journal={The American journal of physiology}, year={1968}, volume={215 4}, pages={788-94} }