Electrical characterization of protein molecules by a solid-state nanopore.

  title={Electrical characterization of protein molecules by a solid-state nanopore.},
  author={Daniel A. Fologea and Bradley Ledden and David S. McNabb and Jiali Li},
  journal={Applied physics letters},
  volume={91 5},
The authors measured ionic current blockages caused by protein translocation through voltage-biased silicon nitride nanopores in ionic solution. By calculating the mean amplitude, time duration, and the integral of current blockages, they estimated the relative charge and size of protein molecules at a single molecule level. The authors measured the change in protein charge of bovine serum albumin (BSA) protein induced by pH variation. They also confirmed that BSA molecules indeed traverse… CONTINUE READING

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