Electrical brain-stimulation paradigm for estimating the seizure onset site and the time to ictal transition in temporal lobe epilepsy

@article{Kalitzin2005ElectricalBP,
  title={Electrical brain-stimulation paradigm for estimating the seizure onset site and the time to ictal transition in temporal lobe epilepsy},
  author={Stiliyan Kalitzin and Demetrios N. Velis and Piotr Suffczynski and Jaime Parra and Fl{\'a}vio Lopes da Silva},
  journal={Clinical Neurophysiology},
  year={2005},
  volume={116},
  pages={718-728}
}
OBJECTIVE To explore and validate a novel stimulation and analysis paradigm proposed to monitor spatial distribution and temporal changes of the excitability state in patients with temporal lobe epilepsy (TLE). METHODS We use intermittent pulse stimulation in the frequency range 10-20Hz. A quantitative measure of spectral phase de-modulation, the relative phase clustering index (rPCI) was applied to the evoked EEG signals, measured from electrodes implanted in the hippocampal formation… CONTINUE READING
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