Electrical activity and development of neural circuits

  title={Electrical activity and development of neural circuits},
  author={Li Zhang and Mu-Ming Poo},
  journal={Nature Neuroscience},
  volume={4 Suppl 1},
A distinct feature of the nervous system is the intricate network of synaptic connections among neurons of diverse phenotypes. Although initial connections are formed largely through molecular mechanisms that depend on intrinsic developmental programs, spontaneous and experience-driven electrical activities in the developing brain exert critical epigenetic influence on synaptic maturation and refinement of neural circuits. Selective findings discussed here illustrate some of our current… CONTINUE READING

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