Electrical activation of endothelium evokes vasodilation and hyperpolarization along hamster feed arteries.

@article{Emerson2001ElectricalAO,
  title={Electrical activation of endothelium evokes vasodilation and hyperpolarization along hamster feed arteries.},
  author={Geoffrey G Emerson and Steven S Segal},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 1},
  pages={H160-7}
}
Endothelial cells are considered electrically unexcitable. However, endothelium-dependent vasodilators (e.g., acetylcholine) often evoke hyperpolarization. We hypothesized that electrical stimulation of endothelial cells could evoke hyperpolarization and vasodilation. Feed artery segments (resting diameter: 63 +/- 1 microm; length 3-4 mm) of the hamster retractor muscle were isolated and pressurized to 75 mmHg, and focal stimulation was performed via microelectrodes positioned across one end of… CONTINUE READING