Electrical Stimulation of Sphenopalatine Ganglion for Acute Treatment of Cluster Headaches

  title={Electrical Stimulation of Sphenopalatine Ganglion for Acute Treatment of Cluster Headaches},
  author={Mehdi Ansarinia and Ali R. Rezai and Stewart J. Tepper and Charles Steiner and Jenna Stump and Michael Stanton‐Hicks and Andr{\'e} Machado and Samer Narouze},
  journal={Headache: The Journal of Head and Face Pain},
(Headache 2010;50:1164‐1174) 

Cluster Headache—Acute and Prophylactic Therapy

(Headache 2011;51:272‐286)

Sphenopalatine Ganglion (SPG): Stimulation Mechanism, Safety, and Efficacy

To describe the history of and available data on sphenopalatine ganglion (SPG) neuromodulation in the treatment of headache up to the present.

The Treatment of Medically Intractable Trigeminal Autonomic Cephalalgia With Supraorbital/Supratrochlear Stimulation: A Retrospective Case Series

Five patients with intractable trigeminal autonomic cephalalgia who were implanted with a supraorbital/supratrochlear neuromodulation system are diagnosed with TAC.

Cluster Headache: Potential Options for Medically Refractory Patients (When All Else Fails)

The most evidence exists for mixed anesthetic/steroid occipital nerve blocks, deep brain stimulation, sphenopalatine ganglion blocks, SPG radiofrequency ablation, and SPG stimulation with the Autonomic Technologies, Inc (ATI) SPG Neurostimulator.

Role of Sphenopalatine Ganglion Stimulation in Cluster Headache

The clinical data and potentially underlying pathophysiological concepts of SPGS are discussed in detail, which point to a relevant role of the parasympathetic system both in the induction and termination of attacks.

Trigeminal Autonomic Cephalalgias: Beyond the Conventional Treatments

At present, the most evidence exists for nerve blocks, deep brain stimulation, occipital nerve stimulation, sphenopalatine ganglion stimulation in chronic cluster headache, and microvascular decompression of the trigeminal nerve in short-lasting unilateral neuralgiform headache attacks.

A Double-Blind, Placebo-Controlled Study of Repetitive Transnasal Sphenopalatine Ganglion Blockade With Tx360® as Acute Treatment for Chronic Migraine

To determine if repetitive sphenopalatine ganglion blocks with 0.5% bupivacaine delivered through the Tx360® are superior in reducing pain associated with chronic migraine (CM) compared with saline, this data indicates that they are superior.


  • Medicine, Psychology
  • 2014
Table of

Burst Occipital Nerve Stimulation for Chronic Migraine and Chronic Cluster Headache

It is now clear in spinal cord stimulation that paraesthesia‐free waveforms can produce effective analgesia, but this has not been reported in ONS for CM or CCH.



Supraorbital Nerve Electric Stimulation for the Treatment of Intractable Chronic Cluster Headache: A Case Report

A patient with intractable chronic cluster headache that responded well to supraorbital nerve electric stimulation is described.

Sphenopalatine Ganglion Radiofrequency Ablation for the Management of Chronic Cluster Headache

Percutaneous radiofrequency ablation of the sphenopalatine ganglion was shown before to improve episodic cluster headache but not chronic cluster headache, and this work was interested in examining the effect of such intervention in patients with intractable chronic cluster headaches who failed pharmacological management.

Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache.

To the Editor: Cluster headache is the most severe form of primary headache.1 Positron-emission tomography has shown activation of the homolateral posterior inferior hypothalamic gray matter during...

Sphenopalatine Ganglionectomy for Cluster Headache

Patients with severe cluster headaches who underwent surgery for removal of the sphenopalatine ganglion obtained little relief, but six-month follow-up of one patient revealed that he was experiencing minimal pain.

Oxygen Inhibits Neuronal Activation in the Trigeminocervical Complex After Stimulation of Trigeminal Autonomic Reflex, But Not During Direct Dural Activation of Trigeminal Afferents

To understand the mechanism of action of oxygen treatment in cluster headache, a large number of patients with cluster headache are treated with oxygen for at least two weeks.

Cluster headache and sphenopalatine block.

A technic of alcohol infiltration of this ganglion is created through a supra-zygomatic way, based on the research of the maxillary nerve by neurostimulation and the bone contact with the pterygoid process for relief of pain and parsympathetic disturbances in 120 cases of cluster headache.

Cluster headache. Local anesthetic abortive agents.

Results indicated that anesthetic rather than sympathomimetic effects are responsible for cocaine-medicated abortion of cluster headache, that transmission of pain in cluster headache likely occurs via the sphenopalatine fossa, and that topical lidocaine is effective in rapidly aborting acute cluster headache.

Sphenopalatine Endoscopic Ganglion Block: A Revision of a Traditional Technique for Cluster Headache

A new technique based on endoscopic ganglion blockade that approaches the pterigo‐palatine fossa by way of the lateral nasal wall and consists of the injection of a mixture of local anesthetics and corticosteroids is adopted, which was performed in 20 selected patients with chronic CH, who were selected for SPG blockade because they were totally drug resistant.

Hypothalamic stimulation for intractable cluster headache: Long-term experience

Hypothalamic stimulation is an effective, safe, and well-tolerated alternative to surgery for chronic patients with drug-refractory CH.