Electrical Stimulation Accelerates and Enhances Expression of Regeneration-Associated Genes in Regenerating Rat Femoral Motoneurons

@article{AlMajed2004ElectricalSA,
  title={Electrical Stimulation Accelerates and Enhances Expression of Regeneration-Associated Genes in Regenerating Rat Femoral Motoneurons},
  author={Abdulhakeem A. Al-Majed and Siu Lin Tam and Tessa Gordon},
  journal={Cellular and Molecular Neurobiology},
  year={2004},
  volume={24},
  pages={379-402}
}
1. In this study we investigated whether electrical stimulation accelerates the upregulation of Tα1-tubulin and GAP-43 (regeneration-associated genes; RAGs) and the downregulation of the medium-molecular-weight neurofilament (NFM), in concert with stimulation-induced acceleration of BDNF and trkB gene expression and axonal regener- ation. 2. Two weeks prior to unilateral femoral nerve transection and suture, fluorogold (Fluorochrome Inc., Denver) or fluororuby (Dextran tetramethylrhodamine, Mol… CONTINUE READING