Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.

Abstract

We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate… (More)
DOI: 10.1016/j.bpj.2010.04.040

Topics

Cite this paper

@article{OjedaMay2010ElectricFD, title={Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.}, author={Pedro Ojeda-May and Mart{\'i}n Garc{\'i}a}, journal={Biophysical journal}, year={2010}, volume={99 2}, pages={595-9} }