Elective transfer of two embryos: Reduction of multiple gestations while maintaining high pregnancy rates

  title={Elective transfer of two embryos: Reduction of multiple gestations while maintaining high pregnancy rates},
  author={Donna Dowling-Lacey and Estella Lynn Jones and Jacob F. Mayer and Silvina M. Bocca and Laurel Stadtmauer and Sergio Oehninger},
  journal={Journal of Assisted Reproduction and Genetics},
Purpose: To determine if the elective transfer of two embryos reduced the incidence of multiple gestations while maintaining high pregnancy rates. Methods: IVF patients and recipients of oocyte donation with an elective day-3 transfer of 2 or 3 embryos were studied. Result(s): In IVF, the elective transfer of 2 embryos resulted in similar pregnancy rate but significantly reduced the overall incidence of multiple gestations (20% versus 39%) when compared to the elective transfer of 3 embryos… 
Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement
Neither late follicular phase serum E2 nor the early E2/P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.
Does the degree of hypothalamic-pituitary-ovarian recovery after oral contraceptive pills affect outcomes of IVF/ICSI cycles receiving GnRH-antagonist adjuvant therapy in women over 35 years of age?
Gonadotropin serum levels after OCP treatment provide information for optimization of supplementation with LH in GnRH-antagonist IVF cycles in women over age 35.
The search for biomarkers of human embryo developmental potential in IVF: a comprehensive proteomic approach.
It is demonstrated that peptide/protein profiles from the culture medium during early human in vitro development can discriminate embryos with highest and lowest implantation competence following uterine transfer.


Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization.
In women under 36 years of age, transferring one fresh embryo and then, if needed, one frozen-and-thawed embryo dramatically reduces the rate of multiple births while achieving a rate of live births that is not substantially lower than the rate that is achievable with a double-embryo transfer.
Impact of elective single embryo transfer on the twin pregnancy rate.
An elective single embryo transfer programme can be adopted in daily practice that decreases the twinning rate to <10% and does not affect the overall pregnancy rate.
Number of embryos for transfer following in-vitro fertilisation or intra-cytoplasmic sperm injection.
Number of Embryos Transferred and Implantation
A retrospective study on cycles performed throughout 2003, analyzing the relation between the number of embryos transferred and the pregnancy and implantation rates, evaluating also the role of the woman's age found the single embryo transfer is a suitable choice for these patients.
Belgian legislation and the effect of elective single embryo transfer on IVF outcome.
Selection of patients suitable for one-embryo transfer may reduce the rate of multiple births by half without impairment of overall birth rates.
A subset of patients at high risk of multiple birth after IVF and hence suitable for one-embryo transfer, which undoubtedly would reduce the multiple birth rate, are identified.
Single embryo transfer is an option in frozen embryo transfer.
SET can be used in frozen cycles to reduce multiple delivery rates and is effective in reducing multiple pregnancy rate in assisted reproduction technology.
Single blastocyst transfer: a prospective randomized trial.
Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization.
Among women undergoing in vitro fertilization, the chances of a live birth are related to the number of eggs fertilized, presumably because of the greater selection of embryos for transfer.
In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial.
A randomized controlled trial was conducted comparing eSET and double embryo transfer (DET) in an unselected group of patients to avoid twin pregnancies resulting from an IVF treatment and found that eSET should be applied in all patients.