Elastomeric microchip electrospray emitter for stable cone-jet mode operation in the nanoflow regime.

Abstract

Despite widespread interest in combining laboratory-on-a-chip technologies with mass spectrometry (MS)-based analyses, the coupling of microfluidics to electrospray ionization (ESI)-MS remains challenging. We report a robust, integrated poly(dimethylsiloxane) microchip interface for ESI-MS using simple and widely accessible microfabrication procedures. The… (More)
DOI: 10.1021/ac8000786

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