Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome.

@article{Lee1981ElastolyticAI,
  title={Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome.},
  author={Catherine Ting Lee and Alan M. Fein and Matthias Lippmann and Henry Holtzman and Philip Kimbel and George Weinbaum},
  journal={The New England journal of medicine},
  year={1981},
  volume={304 4},
  pages={
          192-6
        }
}
To test the hypothesis that adult respiratory-distress syndrome (ARDS) is related to increased activity of the proteolytic enzyme elastase released from neutrophils in the lung, we determined the differential white-cell count, the elastolytic activity, the source of elastase, and the concentration and activity of the endogenous protease inhibitor alpha-1-antiprotease (alpha-1-AP) in bronchoalveolar lavage fluid from 23 patients with ARDS and from 55 patients without this syndrome. Neutrophil… CONTINUE READING
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