Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome.

@article{Lee1981ElastolyticAI,
  title={Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome.},
  author={Catherine T. Lee and Alan M. Fein and M. D. Steven B. Lippmann and Henry Holtzman and Philip Kimbel and George Weinbaum},
  journal={The New England journal of medicine},
  year={1981},
  volume={304 4},
  pages={192-6}
}
To test the hypothesis that adult respiratory-distress syndrome (ARDS) is related to increased activity of the proteolytic enzyme elastase released from neutrophils in the lung, we determined the differential white-cell count, the elastolytic activity, the source of elastase, and the concentration and activity of the endogenous protease inhibitor alpha-1-antiprotease (alpha-1-AP) in bronchoalveolar lavage fluid from 23 patients with ARDS and from 55 patients without this syndrome. Neutrophil… CONTINUE READING