Elastocapillary network model of inhalation

@article{Louf2020ElastocapillaryNM,
  title={Elastocapillary network model of inhalation},
  author={Jean-François Louf and Felix Kratz and Sujit Sankar Datta},
  journal={Physical Review Research},
  year={2020}
}
The seemingly simple process of inhalation relies on a complex interplay between muscular contraction in the thorax, elasto-capillary interactions in individual lung branches, propagation of air between different connected branches, and overall air flow into the lungs. These processes occur over considerably different length and time scales; consequently, linking them to the biomechanical properties of the lungs, and quantifying how they together control the spatiotemporal features of… 

Figures and Tables from this paper

The propagation of air fingers into an elastic branching network

We study experimentally the propagation of an air finger through the Y-bifurcation of an elastic, liquid-filled Hele-Shaw channel, as a benchtop model of airway reopening. With channel compliance

References

SHOWING 1-10 OF 143 REFERENCES

A Morphometric Model of Lung Mechanics for Time-Domain Analysis of Alveolar Pressures during Mechanical Ventilation

TLDR
An anatomically consistent model of the respiratory system in critical care conditions that allows us to evaluate the impact of different ventilator strategies as well as of constrictive pathologies on the time course of acinar pressures and flows is proposed.

CFD investigation of respiratory flows in a space-filling pulmonary acinus model

TLDR
This work has simulated convective flows under rhythmic breathing motion in a space-filling model of an acinar branching tree and emphasizes the role of the alveolar to ductal flow ratio in characterizing acinar flows.

Patterns of recruitment and injury in a heterogeneous airway network model

TLDR
A mathematical multiscale model for the mechanical ventilation of a network of occluded airways, where air is forced into the network at a fixed tidal volume, allowing investigation of optimal recruitment strategies.

Respiratory fluid mechanics.

TLDR
This article covers several aspects of respiratory fluid mechanics that have been actively investigated by this group over the years including liquid plug flow in airways and at airway bifurcations as it relates to surfactant, drug, gene, or stem cell delivery into the lung.

A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness.

Entropy Production and the Pressure–Volume Curve of the Lung

TLDR
This work calculates entropy production in healthy lungs by applying the laws of thermodynamics to the well-known transpulmonary pressure–volume curves of the lung under the assumption that lung tissue behaves as an entropic spring similar to rubber, and uses Clausius's formalism to predict analytically the entropy produced by the fibrotic and emphysematous lungs.

The Mechanics of Lung Tissue under High-Frequency Ventilation

TLDR
This paper describes the use of homogenization theory to predict the macroscopic behavior of lung tissue based upon the three dimensional microstructure of respiratory regions, making the simplifying assumption that the microst structure is periodic.

The mechanics of airway closure

Time dependence of recruitment and derecruitment in the lung: a theoretical model.

TLDR
This model captures the time-dependent mechanical behavior of the lung due to gradual R/D of lung units and predicts that lung elastance will increase transiently after a deep inflation to a degree that increases as lung volume decreases and as the lung becomes injured.

Size distribution of recruited alveolar volumes in airway reopening.

TLDR
In 11 isolated dog lung lobes, the size distribution of recruited alveolar volumes that become available for gas exchange during inflation from the collapsed state is studied and the distribution of the discrete increments in the number of opened alveoli is calculated.
...