Elastin stabilization for treatment of abdominal aortic aneurysms.

  title={Elastin stabilization for treatment of abdominal aortic aneurysms.},
  author={Jason C Isenburg and Dan Teodor Simionescu and Barry C. Starcher and Narendra R Vyavahare},
  volume={115 13},
BACKGROUND Maintaining the integrity of arterial elastin is vital for the prevention of abdominal aortic aneurysm (AAA) development. We hypothesized that in vivo stabilization of aortic elastin with pentagalloyl glucose (PGG), an elastin-binding polyphenol, would interfere with AAA development. METHODS AND RESULTS Safety and efficacy of PGG treatment were first tested in vitro using cytotoxicity, elastin stability, and PGG-elastin interaction assays. For in vivo studies, the efficacy of PGG… CONTINUE READING
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