Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.

@article{Khavandgar2014ElastinHI,
  title={Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.},
  author={Zohreh Khavandgar and Hassem Roman and Jingjing Li and Sara Kay Youny Lee and Hojatollah Vali and Juergen Brinckmann and Elaine C. Davis and Monzur Murshed},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2014},
  volume={29 2},
  pages={327-37}
}
Matrix gla protein (MGP) is a potent inhibitor of extracellular matrix (ECM) mineralization. MGP-deficiency in humans leads to Keutel syndrome, a rare genetic disease hallmarked by abnormal soft tissue calcification. MGP-deficient (Mgp(-/-)) mice show progressive deposition of hydroxyapatite minerals in the arterial walls and die within 2 months of age. The… CONTINUE READING