Elastin-derived peptides upregulate matrix metalloproteinase-2-mediated melanoma cell invasion through elastin-binding protein.

@article{Ntayi2004ElastinderivedPU,
  title={Elastin-derived peptides upregulate matrix metalloproteinase-2-mediated melanoma cell invasion through elastin-binding protein.},
  author={Carole Ntayi and Anne-Laure Labrousse and Romain Debret and Philipe Birembaut and Georges Bellon and Frank Antonicelli and William G Hornebeck and Philipe Bernard},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={122 2},
  pages={256-65}
}
Type I collagen mediates melanoma cells invasion through upregulation of matrix metalloproteinases-1 and -2 (MMP-1 and -2) expression and activation. We investigated here the contribution of elastin-derived peptides (ED), degradation products of elastin, the main component of elastic fibers in melanoma cells invasion and MMP-1 and -2 expression. Our results evidenced fragmentation of elastin at the invasive front of melanoma, particularly in the most invasive tumors where those fibers nearly… CONTINUE READING

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