Elastin-derived peptides induce a T-helper type 1 polarization of human blood lymphocytes.

Abstract

OBJECTIVE Increased level of elastin-derived peptides (EDPs) is observed in the serum of patients with manifestations of arterial diseases. We here investigated whether EDPs might exert, at systemic level, a regulatory role for the T-helper type 1 (Th-1)/Th-2 cellular immune response by human peripheral blood lymphocytes (PBLs) expressing the spliced… (More)

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