Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease.

@article{Pai2011ElastinDA,
  title={Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease.},
  author={Ashwini S Pai and Elizabeth M. Leaf and Mohga M El-Abbadi and Cecilia M. Giachelli},
  journal={The American journal of pathology},
  year={2011},
  volume={178 2},
  pages={764-73}
}
Arterial medial calcification (AMC), a hallmark of vascular disease in uremic patients, is highly correlated with serum phosphate levels and cardiovascular mortality. To determine the mechanisms of AMC, mice were made uremic by partial right-side renal ablation (week 0), followed by left-side nephrectomy at week 2. At 3 weeks, mice were switched to a high-phosphate diet, and various parameters of disease progression were examined over time. Serum phosphate, calcium, and fibroblast growth factor… CONTINUE READING
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