Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases.

@article{Basalyga2004ElastinDA,
  title={Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases.},
  author={Dina M Basalyga and Dan Teodor Simionescu and Wanfen Xiong and Bernard Timothy Baxter and Barry C. Starcher and Narendra R Vyavahare},
  journal={Circulation},
  year={2004},
  volume={110 22},
  pages={3480-7}
}
BACKGROUND Elastin calcification is a widespread feature of vascular pathology, and circumstantial evidence exists for a correlation between elastin degradation and calcification. We hypothesized that matrix metalloproteinase (MMP)-mediated vascular remodeling plays a significant role in elastin calcification. METHODS AND RESULTS In the present studies… CONTINUE READING