Elastin as a matrikine.

  title={Elastin as a matrikine.},
  author={Laurent Duca and Nicolas Floquet and Alain Jean-Paul Alix and Bernard Haye and Laurent Debelle},
  journal={Critical reviews in oncology/hematology},
  volume={49 3},
The fact that elastin peptides, the degradation products of the extracellular matrix protein elastin, are chemotactic for numerous cell types, promote cell cycle progression and induce release of proteolytic enzymes by stromal and cancer cells, strongly suggests that their presence in tissues could contribute to tumour progression. Thus, elastin peptides qualify as matrikines, i.e. peptides originating from the fragmentation of matrix proteins and presenting biological activities. After a brief… CONTINUE READING