Elasticity and rupture of a multi-domain neural cell adhesion molecule complex.

Abstract

The neural cell adhesion molecule (NCAM) plays an important role in nervous system development. NCAM forms a complex between its terminal domains Ig1 and Ig2. When NCAM of cell A and of cell B connect to each other through complexes Ig12(A)/Ig12(B), the relative mobility of cells A and B and membrane tension exerts a force on the Ig12(A)/Ig12(B) complex. In… (More)
DOI: 10.1016/j.bpj.2008.12.3936

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