Elasticity, Stability, and Quasioscillations of Cell-Cell Junctions in Solid Confluent Epithelia.

  title={Elasticity, Stability, and Quasioscillations of Cell-Cell Junctions in Solid Confluent Epithelia.},
  author={Cl{\'e}ment Zankoc and Matej Krajnc},
  journal={Biophysical journal},
2 Citations

Figures from this paper

Generating active T1 transitions through mechanochemical feedback

It is shown that active intercalations can generate stress that activates T1 events in neighbouring cells resulting in tension dependent tissue re-organisation, in qualitative agreement with experiments on gastrulation in chick embryos.

Active Instability and Nonlinear Dynamics of Cell-Cell Junctions.

A mechanical model that describes junctions as dynamic active force dipoles that undergo collective instability to drive active in-plane ordering or develop a limit cycle of collective oscillations, which extends over regions of the energy landscape corresponding to distinct network topologies is studied.



Cell intercalation in a simple epithelium

  • M. Rauzi
  • Materials Science
    Philosophical Transactions of the Royal Society B
  • 2020
Interestingly, in simple epithelia, cells use a combinatory set of mechanisms to ensure a topological transformation at the apical and basal sides, which is an exemplary case of both robustness and plasticity.

Template-based mapping of dynamic motifs in tissue morphogenesis

A “template-based search” approach for accurate mapping of sub- to multi-cellular morphogenetic motifs using a time series data mining framework that enabled statistical analysis of intercalary cell behaviors in wild-type and mutant embryos, comparison of temporal dynamics in contracting and growing junctions in different genotypes, and the identification of a novel mode of iterative cell intercalation.

Solid-fluid transition and cell sorting in epithelia with junctional tension fluctuations.

To identify the solid-fluid transition, this work starts with single-component tissues and shows that the mean cell-shape index uniquely describes the effective diffusion coefficient of cell movements, which becomes finite at the transition.

Linear and nonlinear mechanical responses can be quite different in models for biological tissues.

A simple geometric ansatz is developed that correctly predicts the nonlinear response in 2D vertex models, which may serve as a framework for making nonlinear predictions in other vertex-like models.


A fluid-to-solid jamming transition underlies vertebrate body axis elongation

Cell collectives in embryonic tissues undergo a fluid-to-solid jamming transition, similar to those that occur in soft materials such as foams, emulsions and colloidal suspensions, to physically sculpt the vertebrate body axis.

Fluidization of epithelial sheets by active cell rearrangements.

A coarse-grained theory is developed, where the tissue is treated as an active fluid and the impact of cell rearrangements on tissue shape is illustrated by studying axial compression of an epithelial tube.

Modeling cell intercalation during Drosophila germband extension.

An integrated chemomechanical model is presented that produces the planar cell polarization of key proteins, including Rho-kinase, Bazooka and myosin, the development of anisotropic contractile forces, and subsequent cell deformation and rearrangement.