Elastically Coupled Two-Level Systems as a Model for Biopolymer Extensibility

  title={Elastically Coupled Two-Level Systems as a Model for Biopolymer Extensibility},
  author={Matthias Rief and J. M. Fern{\'a}ndez and Hermann Eduard Gaub},
We present Monte Carlo simulations for the elasticity of biopolymers consisting of segments that can undergo conformational transitions. Based on the thermodynamics of an elastically coupled twolevel system, the probability for a transition and a related change in length of each segment was calculated. Good agreement between this model description and measured data was found for both the polysaccharide dextran where the conformational changes are fast and the muscle protein titin where the… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 10 references


G. I. Bell
618 • 1978
View 5 Excerpts
Highly Influenced


E. Evans, K. Ritchie
J. 72, 1541 • 1997

Science 276

T. Perkins, D. Smith, S. Chu
2016 • 1997


A. Lebrun, R. Lavery
Acids Res. 24, 2260 • 1996
View 1 Excerpt

Science 271

S. B. Smith, Y. Cui, C. Bustamante
795 • 1996
View 2 Excerpts

Macromolecules 28

J. F. Marko, E. D. Siggia
8759 • 1995
View 2 Excerpts

Science 264

E.-L. Florin, V. T. Moy, H. E. Gaub
415 • 1994

Science 258

S. B. Smith, L. Finzi, C. Bustamante
1122 • 1992
View 1 Excerpt


M. Fixman, J. Kovac, J. Chem
58, 1564 • 1973


O. Kratky, G. Porod
Trav. Chim. 68, 1106 • 1949

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