Elastic fibers in scar tissue

  title={Elastic fibers in scar tissue},
  author={S V Roten and S Bhat and Jag Bhawan},
  journal={Journal of Cutaneous Pathology},
The capacity of the skin to be stretched and to return to its resting position is correlated to the quantity and to the quality of the elastic fiber network. Although elastic fibers have been demonstrated in scars, the time course of their appearance in scars and their role in scar elasticity has not been elucidated. A study was therefore undertaken to evaluate the elastic fiber network in scars. 
The Role of Elastin in Wound Healing and Dermal Substitute Design
The integrity of the elastic fiber network is a strong determinant of the skin’s elasticity, resilience, quality, and texture and its importance is particularly exemplified by the severity of skin impairment in various genetic disorders that affect elastin expression in the dermis.
Elastic Fibres in the subcutaneous tissue: Is there a difference between superficial and muscular fascia? A cadaver study
  • C. Pirri, C. Fede, C. Stecco
  • Medicine
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
  • 2021
The aim of the study was to assess the percentage of elastic fibres between superficial and deep fascia.
Elastic fiber pattern in scleroderma/morphea
A systematic study of the elastic fiber pattern correlated with CD34 expression is reported in scleroderma/morphea, characterized by expansion of the dermis with thickened collagen bundles and loss of CD34+ dermal dendrocytes.
The Role of Elastic Fibers in Scar Formation and Treatment
The literature is reviewed to summarize the role of elastin in the formation scars, as well as treatment via therapeutic lasers, using ablative, nonablative, and fractional laser devices for the treatment of scars.
Advances in biomimetic regeneration of elastic matrix structures
An overview of the role and importance of elastin and elastic matrix in soft tissues, the challenges to elastic matrix generation in vitro and to regenerative elastic matrix repair in vivo, current biomolecular strategies to enhanceElastin deposition and matrix assembly, and the need to concurrently inhibit proteolytic matrix disruption for improving the quantity and quality ofElastogenesis are provided.
Marked disruption and aberrant regulation of elastic fibres in early striae gravidarum
Striae gravidarum (SG), or ‘stretch marks’ of pregnancy, begin as erythematous streaks, and mature over months to years to become permanent scar‐like bands that may be hypopigmented, atrophic and lax.
Elastin Based Constructs
This chapter considers the mechanical and biochemical roles of elastin in elastic tissues and the subsequent disease phenotypes that result from the degradation and loss of Elastin, the development and success of current elastIn based biomaterials including sources ofElastin for tissue engineering and their application, and vascular constructs that the laboratory has developed from recombinant human tropoelastin.
Morphometric analyses of elastic tissue fibers in dermatofibroma: clues to etiopathogenesis?
The goal of this study was to ascertain the density of elastic tissue fibers in DF in an effort to investigate whether this provides an insight into its etiopathogenesis.
Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars
  • Hua Xie, L. Lucchesi, K. Gregory
  • Medicine
    Journal of burn care & research : official publication of the American Burn Association
  • 2017
This is the first report demonstrating that subcutaneous injections of TE into surgical and burn injuries can safely produce new elastin fibers in scars, and despite the development of new elASTin fibers, skin flexibility was not improved.


Scar tissue, obtained from humans, was stained for elastin fibers by a new staining method and practically noElastin was found in keloids.
Elastic tissue changes in skin following PUVA therapy.
Elastin and Elastic Fibers in Normal and Pathologic Skin
Although the elastic tissue has been relatively ignored by dermatologists compared with the other elements of the dermis, its elastic properties make its physiologic role of prime importance for all
Wound Contraction in Relation to Collagen Formation in Scorbutic Guinea-pigs
Wounds made on guinea-pigs receiving a diet devoid of ascorbic acid are measured, finding that the course of the contraction of skin wounds in rats did not parallel the deposition of new collagen, chemically measured.
Histological Study of Fibrogenesis in Experimental Inflammation with Special Reference to Elastic Tissue Formation
The behaviour of the fibres which required oxidation before being stained and elastic fibres in relation to each other suggest that the former may be regarded as pre-elastic fibres.
Elastic fibers in scar tissue: scanning and transmission electron microscopic studies
Findings suggestive of newly synthesized elastic fibers were seen in some hypertrophic scar tissue and SEM and TEM indicated that there is elastogenesis in scar tissue.
Studies in cutaneous aging: I. The elastic fiber network.
It is proposed that one of the features of cutaneous aging is a slow, spontaneous, progressive degradative process inherent in the elastic fiber that can be enzymatically accelerated from decades to hours by elastase and chymotrypsin.
Oxytalan, elaunin, and elastic fibers in the human skin.
The elastic system of normal human skin was studied by light and electron microscopy and found that in the elaunin fibers the amorphous material is sparse, while in the elastic fibers it is abundant and compact.
The histiotypic organization of the hypertrophic scar in humans.
It is concluded that hypertrophic scarring involves the formation of collagenous nodules composed of tightly packed collagen, which appears to reflect the most active and the worst phase of hypertrophic Scarring.
Selective staining technique for identification of human skin elastic fibers.
Several staining methods are worked out which enable to obtain a selective staining of all the elastic and pre-elastic fibers with noStaining of the background by using in the staining solution polyphenols like: pyrogallol, (+) catechin, tannic acid and others.