Elastic fiber homeostasis requires lysyl oxidase–like 1 protein

  title={Elastic fiber homeostasis requires lysyl oxidase–like 1 protein},
  author={Xiaoqing Liu and Yun M. Zhao and Jiangang Gao and Basil S. Pawlyk and Barry Starcher and Jeffrey A. Spencer and Hiromi Yanagisawa and Jian Zuo and Tiansen Li},
  journal={Nature Genetics},
Elastic fibers are components of the extracellular matrix and confer resilience. Once laid down, they are thought to remain stable, except in the uterine tract where cycles of active remodeling occur. Loss of elastic fibers underlies connective tissue aging and important diseases including emphysema. Failure to maintain elastic fibers is explained by a theory of antielastase-elastase imbalance, but little is known about the role of renewal. Here we show that mice lacking the protein lysyl… CONTINUE READING
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