Elastic fiber homeostasis requires lysyl oxidase–like 1 protein

  title={Elastic fiber homeostasis requires lysyl oxidase–like 1 protein},
  author={X. Liu and Y. Zhao and Jiangang Gao and B. Pawlyk and B. Starcher and J. A. Spencer and H. Yanagisawa and J. Zuo and T. Li},
  journal={Nature Genetics},
  • X. Liu, Y. Zhao, +6 authors T. Li
  • Published 2004
  • Medicine, Biology
  • Nature Genetics
  • Elastic fibers are components of the extracellular matrix and confer resilience. Once laid down, they are thought to remain stable, except in the uterine tract where cycles of active remodeling occur. Loss of elastic fibers underlies connective tissue aging and important diseases including emphysema. Failure to maintain elastic fibers is explained by a theory of antielastase-elastase imbalance, but little is known about the role of renewal. Here we show that mice lacking the protein lysyl… CONTINUE READING
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