Elastase mimics pancreatitis-induced hepatic injury via inflammatory mediators.

  title={Elastase mimics pancreatitis-induced hepatic injury via inflammatory mediators.},
  author={Colleen E Jaffray and Jun Yang and James C Norman},
  journal={The Journal of surgical research},
  volume={90 2},
BACKGROUND Recent evidence suggests that pancreatitis-associated hepatic injury is regulated by inflammatory mediator production. Our laboratory demonstrated in vitro that pancreatic elastase is a pancreatic enzyme that can induce inflammatory cell cytokine production. Therefore we now explore the in vivo effects of elastase on the liver. MATERIALS AND METHODS Elastase (1.5 U) +/- CNI-1493, which attenuates mediator production through p38 MAP kinase inhibition, was administered… CONTINUE READING


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