Elastase is a constituent product of T cells.


Proteases produced by immune cells have been found to be important components of the immune response to antigen. A protease previously unrecognized as a specific T cell product has been identified which has the gene sequence, serologic crossreactivity, and enzymatic specificity of elastase. T cell elastase, found in combination with the natural elastase inhibitor alpha 1-antitrypsin (alpha 1-protease inhibitor, alpha 1-PI), is produced by both CD4+ and CD8+ T lymphocytes, and is found both in a membrane-bound and in a soluble form in murine T cell lines.

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@article{Bristow1991ElastaseIA, title={Elastase is a constituent product of T cells.}, author={Cynthia L. Bristow and Lisa K Lyford and David P. Stevens and Patrick M. Flood}, journal={Biochemical and biophysical research communications}, year={1991}, volume={181 1}, pages={232-9} }