Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.

@article{Hagio2004ElastaseIR,
  title={Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.},
  author={Tetsuya Hagio and Shigeru Matsumoto and Shintaro Nakao and Taira Abiru and Hiroyuki Ohno and Kazuhito Kawabata},
  journal={European journal of pharmacology},
  year={2004},
  volume={488 1-3},
  pages={173-80}
}
This study examined whether the specific inhibition of neutrophil elastase by sivelestat sodium hydrate (sivelestat) reduced deaths associated with severe acute lung injury after hydrochloric acid (HCl) aspiration in hamsters. Animals that received a single intratracheal instillation of HCl (0.2 N, 200 microL) time-dependently died by occlusion of their… CONTINUE READING