Elastase derived elastin peptides: putative autoimmune targets in giant cell arteritis.


OBJECTIVE Histological analysis of giant cell arteritis (GCA) reveals a granulomatous reaction around the internal elastic lamina. Elastolysis by multinucleated giant cells has also been reported. We investigated elastin derived peptides as putative recall antigens for peripheral blood mononuclear cells (PBMC) from patients with GCA. METHODS PBMC were… (More)


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