Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease.

@article{Cowan2000ElastaseAM,
  title={Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease.},
  author={Kyle N Cowan and Peter Lloyd Jones and Marlene Rabinovitch},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={105 1},
  pages={21-34}
}
Increased expression of the glycoprotein tenascin-C (TN) is associated with progression of clinical and experimental pulmonary hypertension. In cultured smooth muscle cells (SMCs) TN is induced by matrix metalloproteinases (MMPs) and amplifies the proliferative response to growth factors. Conversely, suppression of TN leads to SMC apoptosis. We now report… CONTINUE READING