Elafin-overexpressing mice have improved cardiac function after myocardial infarction.

  title={Elafin-overexpressing mice have improved cardiac function after myocardial infarction.},
  author={Kunio Ohta and Takanori Nakajima and Alexander Y L Cheah and Syed Hassan Ejaz Zaidi and Nilo Kaviani and Fayez Dawood and X You and Peter J Y Liu and Mansoor Husain and Marlene Rabinovitch},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={287 1},
Elevated serine elastase activity after myocardial infarction can contribute to remodeling associated with left ventricular dilatation and dysfunction. We therefore assessed the effects of overexpressing the selective serine elastase inhibitor elafin in transgenic mice in which a myocardial infarction was caused by ligation of the left anterior descending coronary artery (LAD). Elevated serine elastase activity was observed in nontransgenic littermates as early as 6 h after LAD ligation and… CONTINUE READING
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