Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI.

@article{Thermenos2007ElaborativeVE,
  title={Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI.},
  author={Heidi W. Thermenos and Larry J. Seidman and Russell A. Poldrack and Nicole K Peace and Jennifer K. Koch and Stephen V Faraone and Ming T. Tsuang},
  journal={Biological psychiatry},
  year={2007},
  volume={61 4},
  pages={564-74}
}
BACKGROUND First-degree relatives of persons with schizophrenia are at elevated risk for the illness, demonstrate deficits in verbal memory, and exhibit structural abnormalities in the medial temporal lobe (MTL). We used functional magnetic resonance imaging (fMRI) to assess brain activity in the MTL during novel and repeated word-pair encoding. METHODS Participants were 21 non-psychotic, first-degree relatives of persons with schizophrenia and 26 matched healthy controls (ages 13-28). fMRI… CONTINUE READING

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