El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis

@article{Brooks2000ElER,
  title={El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis},
  author={Benjamin Rix Brooks and Robert G. Miller and Michael Swash and Theodore L. Munsat},
  journal={Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders},
  year={2000},
  volume={1},
  pages={293 - 299}
}
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving primarily motor neurons in the cerebral cortex, brainstem and spinal cord. The variability in clinical Žndings early in the course of ALS and the lack of any biological diagnostic marker make absolute diagnosis difŽcult and compromise the certainty of diagnosis in clinical practice, therapeutic trials and other research purposes. The El Escorial criteria for the diagnosis of ALS have been widely accepted… 
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