Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation.

  title={Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation.},
  author={K. K. Kang and G. J. Ahn and J. Sung and S. H. Kim and H. Kim and S. Lee},
  volume={81 4},
  • K. K. Kang, G. J. Ahn, +3 authors S. Lee
  • Published 2013
  • Medicine
  • Urology
  • OBJECTIVE To investigate the efficacy of DA-8031, a novel compound for the treatment of premature ejaculation (PE), we performed in vivo pharmacological studies using 2 preclinical animal models, electrical stimulation of sensory branch of pudendal nerve (SBPdn) and para-chloroamphetamine (PCA)-induced ejaculation model. METHODS First of all, in electrical stimulation of an SBPdn model, an SBPdn in the pelvic canal of the spinal cord transected from rats was identified. Then an electromyogram… CONTINUE READING
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