Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation.

@article{Kang2013EjaculatoryRA,
  title={Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation.},
  author={Kyung Koo Kang and Gook Jun Ahn and Ji Hyun Sung and Soon Hoe Kim and Hyunah Kim and Sukhyang Lee},
  journal={Urology},
  year={2013},
  volume={81 4},
  pages={920.e13-8}
}
OBJECTIVE To investigate the efficacy of DA-8031, a novel compound for the treatment of premature ejaculation (PE), we performed in vivo pharmacological studies using 2 preclinical animal models, electrical stimulation of sensory branch of pudendal nerve (SBPdn) and para-chloroamphetamine (PCA)-induced ejaculation model. METHODS First of all, in electrical stimulation of an SBPdn model, an SBPdn in the pelvic canal of the spinal cord transected from rats was identified. Then an electromyogram… CONTINUE READING
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Emerging and investigational drugs for premature ejaculation

Translational andrology and urology • 2016
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Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior.

International journal of urology : official journal of the Japanese Urological Association • 2014

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