Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation.
@article{Kang2013EjaculatoryRA, title={Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation.}, author={K. K. Kang and G. J. Ahn and J. Sung and S. H. Kim and H. Kim and S. Lee}, journal={Urology}, year={2013}, volume={81 4}, pages={ 920.e13-8 } }
OBJECTIVE
To investigate the efficacy of DA-8031, a novel compound for the treatment of premature ejaculation (PE), we performed in vivo pharmacological studies using 2 preclinical animal models, electrical stimulation of sensory branch of pudendal nerve (SBPdn) and para-chloroamphetamine (PCA)-induced ejaculation model.
METHODS
First of all, in electrical stimulation of an SBPdn model, an SBPdn in the pelvic canal of the spinal cord transected from rats was identified. Then an electromyogram… CONTINUE READING
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References
SHOWING 1-10 OF 28 REFERENCES
Role of peripheral innervation in p-chloroamphetamine-induced ejaculation in anesthetized rats.
- Biology, Medicine
- Journal of andrology
- 2006
- 22
Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine.
- Medicine
- European urology
- 2007
- 41
Evidence for an involvement of peripheral serotonin in p-chloroamphetamine-induced ejaculation of rats
- Medicine
- Pharmacology Biochemistry and Behavior
- 2005
- 12
- Highly Influential
Evaluation of the excopula ejaculatory potentials of Bersama engleriana in spinal male rats.
- Medicine
- Asian journal of andrology
- 2009
- 11
- PDF
Yohimbine reverses the exhaustion of the coital reflex in spinal male rats
- Psychology, Medicine
- Behavioural Brain Research
- 2003
- 30
Activation of lumbosacral 5‐HT2C receptors induces bursts of rhythmic activity in sympathetic nerves to the vas deferens in male rats
- Biology, Medicine
- British journal of pharmacology
- 2006
- 32
Peripheral effects of serotonin on the contractile responses of rat seminal vesicles and vasa deferentia.
- Biology, Medicine
- Journal of andrology
- 2004
- 28
Seminal Plug Expulsion Induced by Electrical Stimulation of the Intermesenteric Nerve in Anesthetized Rats
- Biology, Medicine
- Biology of reproduction
- 2007
- 9
- PDF
Effect of acute dapoxetine administration on the pudendal motoneuron reflex in anesthetized rats: comparison with paroxetine.
- Medicine
- The Journal of urology
- 2007
- 24