Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.

@article{Itoda2003EightNS,
  title={Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.},
  author={Masaya Itoda and Yoshiro Saito and Kuniaki Shirao and Hironobu Minami and Atsushi Ohtsu and Teruhiko Yoshida and Nagahiro George Saijo and Hiroshi Suzuki and Yuichi Sugiyama and Shogo Ozawa and Jun-ichi Sawada},
  journal={Drug metabolism and pharmacokinetics},
  year={2003},
  volume={18 3},
  pages={212-7}
}
Eight novel single nucleotide polymorphisms (SNPs) were found in the gene encoding the ATP-binding cassette transporter, ABCG2/BCRP, from 60 Japanese individuals administered the anti-cancer drug irinotecan. The detected SNPs were as follows: 1) SNP, MPJ6_AG2005 (IVS2-93T>C); Gene Name, ABCG2; Accession Number, NT_006204; 2) SNP, MPJ6_AG2007 (IVS3+71_72 insT); Gene Name, ABCG2; Accession Number, NT_006204; 3) SNP, MPJ6_AG2012 (IVS6-204C>T); Gene Name, ABCG2; Accession Number, NT_006204; 4) SNP… CONTINUE READING

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