Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.

@article{Hasan2015EicosapentaenoicAU,
  title={Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.},
  author={Arif Ul Hasan and Koji Ohmori and Kumi Konishi and Junsuke Igarashi and Takeshi Hashimoto and Kazuyo Kamitori and Fuminori Yamaguchi and Ikuko Tsukamoto and Toru Uyama and Yasuhiro Ishihara and Takahisa Noma and Masaaki Tokuda and Masakazu Kohno},
  journal={Molecular and cellular endocrinology},
  year={2015},
  volume={406},
  pages={10-8}
}
Vascular endothelial growth factor-A (VEGF-A) released from adipocytes promotes angiogenesis; and thereby ameliorates the local hypoxia-induced adipose inflammation and insulin resistance. Here, we newly found that eicosapentaenoic acid (EPA) upregulated both mRNA expression and release of VEGF-A in mature 3T3-L1 adipocytes. Silencing mRNA of G-protein coupled receptor 120 (GPR120) and specific inhibition of peroxisome proliferator-activated receptor γ (PPARγ) by GW9662 respectively attenuated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
15 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…