Eicosapentaenoic acid interferes with U46619-stimulated formation of inositol phosphates in washed rabbit platelets.

@article{Chetty1989EicosapentaenoicAI,
  title={Eicosapentaenoic acid interferes with U46619-stimulated formation of inositol phosphates in washed rabbit platelets.},
  author={N Chetty and James L Vickers and Raelene L. Kinlough-Rathbone and Marian A. Packham and James Fraser Mustard},
  journal={Thrombosis and haemostasis},
  year={1989},
  volume={62 4},
  pages={
          1116-20
        }
}
Eicosapentaenoic acid (EPA) inhibits platelet responsiveness to aggregating agents. To investigate the reactions that are affected by EPA, we examined the effect of preincubating aspirin-treated rabbit platelets with EPA on stimulation of inositol phosphate formation in response to the TXA2 analogue U46619. Stimulation of platelets with U46619 (0.5 microM) caused aggregation and slight release of dense granule contents; aggregation and release were inhibited by preincubation of the platelets… CONTINUE READING