Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells.

@article{Obata1999EicosapentaenoicAI,
  title={Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells.},
  author={Toru Obata and Toshikazu Nagakura and Tbmoh Masaki and Kazuyo Maekawa and Kamejiro Yamashita},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={1999},
  volume={29 8},
  pages={1129-35}
}
BACKGROUND Eicosapentaenoic acid (EPA) is catalysed by cyclo-oxygenase (COX), as is arachidonic acid, and is a competitive inhibitor of arachidonate metabolism. OBJECTIVES We examined the effect of EPA on prostaglandin (PG) D2 generation in the cultured human mast cells with IgE-anti-IgE challenge incubation. METHODS Cultured human mast cells were incubated with EPA (1 micromol/L) for 20 h, then challenged with anti-IgE incubation after treatment with IgE. At the same time, COX inhibitors… CONTINUE READING