Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover.

@article{Puri2001EicosapentaenoicAI,
  title={Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover.},
  author={Basant K. Puri and Serena J. Counsell and Gill Hamilton and Alexandra J. Richardson and David F. Horrobin},
  journal={International journal of clinical practice},
  year={2001},
  volume={55 8},
  pages={560-3}
}
The n-3 essential fatty acid eicosapentaenoic acid (EPA) was added to the conventional antidepressant treatment of a treatment-resistant severely depressed and suicidal male patient with a seven-year history of unremitting depressive symptoms. The niacin skin flush test and cerebral magnetic resonance scanning were carried out at baseline and nine months later. The addition of ethyl-EPA led to a dramatic and sustained clinical improvement in all the symptoms of depression, including a cessation… CONTINUE READING
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