Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus.

@article{Lynch2007EicosapentaenoicAC,
  title={Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus.},
  author={Aileen M Lynch and David J. Loane and Aed{\'i}n M. Minogue and Rachael M Clarke and Dana Kilroy and Rachel E Nally and Oran J Roche and Florence O'Connell and Marina A. Lynch},
  journal={Neurobiology of aging},
  year={2007},
  volume={28 6},
  pages={845-55}
}
Among the changes that occur in the hippocampus with age, is a deficit in long-term potentiation (LTP). This impairment is associated with inflammatory changes, which are typified by increased concentration of the pro-inflammatory cytokine interleukin-1beta (IL-1beta). Activated microglia are the most likely cell source of IL-1beta, but data demonstrating an age-related increase in microglial activation is equivocal. Here we demonstrate that the age-related deficit in LTP is accompanied by… CONTINUE READING