Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice

@inproceedings{Johnson2015EicosapentaenoicAB,
  title={Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice},
  author={Matthew L. Johnson and Antigoni Z. Lalia and Surendra Dasari and Maximilian Pallauf and Mark J Fitch and Marc K. Hellerstein and Ian R. Lanza},
  booktitle={Aging cell},
  year={2015}
}
Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) supplementation partially attenuated the age-related decline in mitochondrial function in mice, but this effect was not observed with docosahexaenoic acid (DHA). The improvement in… CONTINUE READING
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