Eicosapentaenoic acid attenuates arthritis-induced muscle wasting acting on atrogin-1 and on myogenic regulatory factors.

@article{Castillero2009EicosapentaenoicAA,
  title={Eicosapentaenoic acid attenuates arthritis-induced muscle wasting acting on atrogin-1 and on myogenic regulatory factors.},
  author={Est{\'i}baliz Castillero and Ana Isabel Mart{\'i}n and Mar{\'i}a L{\'o}pez-Mendui{\~n}a and Mar{\'i}a Angeles Villan{\'u}a and Asunci{\'o}n L{\'o}pez-Calder{\'o}n},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2009},
  volume={297 5},
  pages={R1322-31}
}
Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid that has anti-inflammatory and anticachectic actions. The aim of this work was to elucidate whether EPA administration is able to prevent an arthritis-induced decrease in body weight and muscle wasting in rats. Arthritis was induced by intradermal injection of Freund's adjuvant; 3 days later, nine rats received 1 g/kg EPA or coconut oil daily. All rats were killed 15 days after adjuvant injection. EPA administration decreased… CONTINUE READING
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