Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding.

@article{Horrobin2002EicosapentaenoicAA,
  title={Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding.},
  author={DavidF. Horrobin and Karen M. Jenkins and Crispin N. Bennett and William Walker Christie},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2002},
  volume={66 1},
  pages={
          83-90
        }
}
Much of the literature on omega-3 and omega-6 fatty acids suggests that desirable effects of omega-3 fatty acids are in part related to depletion of arachidonic acid (AA). However, in rats and humans, we have found that low doses of EPA actually elevate membrane AA phospholipid concentrations. In patients with schizophrenia, treatment with eicosapentaenoic acid (EPA) produced clinical improvement, but that improvement was greater at a dose of 2 g/day than at 4 g/day. The improvement was not… CONTINUE READING
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