Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.

@article{Unoda2013EicosapentaenoicA,
  title={Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.},
  author={Kiichi Unoda and Yoshimitsu Doi and Hideto Nakajima and Kazushi Yamane and Takafumi Hosokawa and Shimon Ishida and Fumiharu Kimura and Toshiaki Hanafusa},
  journal={Journal of neuroimmunology},
  year={2013},
  volume={256 1-2},
  pages={7-12}
}
Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, is a neuroprotective lipid with anti-inflammatory properties. We investigated the possible therapeutic effect of EPA on experimental autoimmune encephalomyelitis (EAE). EAE mice were fed a diet with or without EPA. The clinical EAE scores of the EPA-fed mice were significantly lower than those of the non-EPA mice. In the EPA-treated mice, IFN-γ and IL-17 productions were remarkably inhibited and the expression levels of… CONTINUE READING
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