Eicosanoids in synaptic transmission.

  title={Eicosanoids in synaptic transmission.},
  author={Danlele Piomelli},
  journal={Critical reviews in neurobiology},
  volume={8 1-2},
Arachidonic acid is released from membrane phospholipids in a receptor-dependent manner when neurons or glial cells are stimulated with neurotransmitters, hormones, or growth factors. The released fatty acid can be metabolized in brain tissue by three enzymatic pathways--cyclooxygenase, lipoxygenase, and cytochrome P450--giving rise to a series of… CONTINUE READING