Eicosanoids in insect immunity: bacterial infection stimulates hemocytic phospholipase A2 activity in tobacco hornworms.

@article{Tunaz2003EicosanoidsII,
  title={Eicosanoids in insect immunity: bacterial infection stimulates hemocytic phospholipase A2 activity in tobacco hornworms.},
  author={Hasan Tunaz and Youngjin Park and Kemal B{\"u}y{\"u}kg{\"u}zel and Jon C. Bedick and A R Nor Aliza and David Warren Stanley},
  journal={Archives of insect biochemistry and physiology},
  year={2003},
  volume={52 1},
  pages={1-6}
}
Intracellular phospholipase A(2) (PLA(2)) is responsible for releasing arachidonic acid from cellular phospholipids, and is thought to be the first step in eicosanoid biosynthesis. Intracellular PLA(2)s have been characterized in fat body and hemocytes from tobacco hornworms, Manduca sexta. Here we show that bacterial challenge stimulated increased PLA(2) activity in isolated hemocyte preparations, relative to control hemocyte preparations that were challenged with water. The increased activity… CONTINUE READING