Eicosanoids in inflammation and cancer: the role of COX-2.

  title={Eicosanoids in inflammation and cancer: the role of COX-2.},
  author={Smita Agarwal and Gorla Venkateswara Reddy and Pallu Reddanna},
  journal={Expert review of clinical immunology},
  volume={5 2},
Eicosanoids, a family of oxygenated metabolites of eicosapolyenoic fatty acids, such as arachidonic acid, formed via the lipoxygenase, cyclooxygenase (COX) and epoxygenase pathways, play an important role in the regulation of various pathophysiological processes, including inflammation and cancer. COX-2, the inducible isoform of COX, has emerged as the key enzyme regulating inflammation, and promises to play a considerable role in cancer. Although NSAIDs have been in use for centuries, the COX… CONTINUE READING


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