Eicosanoid synthesis elicited by norepinephrine in piglet parietal cortex.

  title={Eicosanoid synthesis elicited by norepinephrine in piglet parietal cortex.},
  author={David William Busija and Charles W. Leffler},
  journal={Brain research},
  volume={403 2},
We investigated effects of exogenous norepinephrine and isoproterenol on pial arterial diameter and cerebral eicosanoid synthesis in anesthetized newborn pigs. Norepinephrine in artificial cerebrospinal fluid (CSF) constricted pial arteries from 203 +/- 27 micron (X +/- S.E.M.) to 164 +/- 18 micron (20 +/- 2%) (n = 21 vessels from 16 animals) at 10(-4) M. In the same animals, norepinephrine caused the concentration in CSF of 6-keto-prostaglandin F1 alpha to increase from 768 +/- 91 to 1544… CONTINUE READING
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