Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

@article{Cathcart2011EicosanoidSP,
  title={Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention},
  author={Mary-Clare Cathcart and Joanne Lysaght and Graham P. Pidgeon},
  journal={Cancer and Metastasis Reviews},
  year={2011},
  volume={30},
  pages={363-385}
}
Arachidonic acid metabolism through cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P-450 epoxygenase (EPOX) pathways leads to the generation of biologically active eicosanoids, including prostanoids, leukotrienes, hydroxyeicosatetraenoic acid, epoxyeicosatrienoic acid and hydroperoxyeicosatetraenoic acids. Eicosanoid expression levels vary during tumor development and progression of a range of malignancies, including colorectal cancer. The actions of these autocoids are also directly… CONTINUE READING
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